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Search results “Principles of meta analysis”
IPPCR 2015: Secondary Data/Meta-Analysis
 
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Introduction to the Principles and Practice of Clinical Research (IPPCR) 2015: Secondary Data/Meta-Analysis Air date: Tuesday, December 08, 2015, 5:00:00 PM Category: IPPCR Runtime: 00:53:33 Description: The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues. For more information go to http://clinicalcenter.nih.gov/training/training/ippcr1.html Author: Charles Natanson, M.D., NIH Permanent link: http://videocast.nih.gov/launch.asp?19374
Views: 2862 nihvcast
Systematic Reviews and MetaAnalysis
 
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More info on www.amzn.to/1XhxciA
Epidemiological Studies - made easy!
 
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This video gives a simple overview of the most common types of epidemiological studies, their advantages and disadvantages. These include ecological, case-series, case control, cohort and interventional studies. It also looks at systematic reviews and meta-analysis. This video was created by Ranil Appuhamy Voiceover - James Clark -------------------------------------------------------------------------------------------------------- Disclaimer: These videos are provided for educational purposes only. Users should not rely solely on the information contained within these videos and is not intended to be a substitute for advice from other relevant sources. The author/s do not warrant or represent that the information contained in the videos are accurate, current or complete and do not accept any legal liability or responsibility for any loss, damages, costs or expenses incurred by the use of, or reliance on, or interpretation of, the information contained in the videos.
BroadE: Statistical Genetics - Meta-analysis
 
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Copyright Broad Institute, 2013. All rights reserved. BroadE: Statistical Genetics - Meta-analysis - Daniel Howrigan These presentations were filmed during the September 2013 Statistical Genetics Workshop, part of the BroadE Workshop series. This workshop provides an introduction to the basic principles of statistical genetic analysis. This course is targeted for individuals who are interested in learning the basics of genetic analysis. Specific areas of focus for the course include: study design considerations for genetic association tests, quality control (QC) procedures for genetic data, basic analysis of genome-wide association SNP data, and introduction to rare variant testing approaches. The workshop blended lectures introducing each of these topics and then hands-on practical application, in particular for QC and common variant analysis. Website: http://www.broadinstitute.org/partnerships/education/broade/broade-statistical-genetics About Broad Workshops BroadE workshops bring researchers in the extended Broad community together so they can learn from one another. BroadE workshops (the 'E' stands for education) offer insights and share hands-on training in breakthrough technologies, high-throughput methods, and computational tools not typically found in conventional research labs. Through this ongoing series, which is open to Broad staff and to researchers at MIT, Harvard and Harvard-affiliated hospitals, the Broad community hopes to extend the impact of its science and openly share new methods. Website: http://www.broadinstitute.org/partnerships/education/broade/broad-workshops
Views: 1915 Broad Institute
Introduction to GRADE for NMA
 
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This is the second part of a Cochrane Learning Live webinar with the aim of increasing familiarity in interpreting findings of network meta-analysis (NMA) through a NMA ‘Summary of findings’ (SoF) tables developed based on principles of the GRADE approach to rating certainty of evidence from NMAs. The presenters on this webinar were Juan José Yepes-Nuñez and Holger J Schünemann from McMaster University
Views: 152 Cochrane Training
80/20 principle - How to Study and Do more in Less Time - Book recommendations
 
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How to be productive every day The 80/20 Principle by Richard Koch When it comes to studying or work, we want to be more productive. For the book click here: http://goo.gl/Q0g8iH How to be more productive In 1896, the Italian economist Vilfredo Pareto noticed that 80% of Italy's land was owned by 20% of the population. The idea is really simple it states that 80 percent of works result or output is produced by 20 percent of the work effort or input, but in reality, the ratio can differ but the idea of imbalance remains the same. The majority of effects come from the minority of causes. For a video on the 100$ startup: https://www.youtube.com/watch?v=jt7zejBdXZQ https://www.facebook.com/LonelyBookaneer/ https://twitter.com/LonelyBookaneer https://www.instagram.com/lonelybookaneer/
Views: 22792 RealizeTheImpossible
9.1 Meta-analysis, for ITNS book
 
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Meta-analysis, forest plot, diamond. ESCI intro Meta-Analysis, Original two groups. McCabe and Michael brain picture example. Study weights, fixed effect and random effects models, diamond ratio, heterogeneity. This is a video to go with the book: Introduction to The New Statistics: Estimation, Open Science, and Beyond (Routledge 2017) by Geoff Cumming & Robert Calin-Jageman. See: www.thenewstatistics.com
Views: 134 Geoff Cumming
Introduction to NMA
 
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This is the first part of a Cochrane Learning Live webinar with the aim of increasing familiarity in interpreting findings of network meta-analysis (NMA) through a NMA ‘Summary of findings’ (SoF) tables developed based on principles of the GRADE approach to rating certainty of evidence from NMAs. The presenters on this webinar were Juan José Yepes-Nuñez and Holger J Schünemann from McMaster University
Views: 27 Cochrane Training
Introduction to NMA
 
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This is the first part of a Cochrane Learning Live webinar with the aim of increasing familiarity in interpreting findings of network meta-analysis (NMA) through a NMA ‘Summary of findings’ (SoF) tables developed based on principles of the GRADE approach to rating certainty of evidence from NMAs. The presenters on this webinar were Juan José Yepes-Nuñez and Holger J Schünemann from McMaster University
Views: 213 Cochrane Training
Introduction to HACCP Principles
 
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An educational video targeted at meat and food processing plant employees.
Cohort, Case-Control, Meta-Analysis, Cross-sectional Study Designs & Definition
 
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http://www.stomponstep1.com/cohort-case-control-meta-analysis-cross-sectional-study-designs/ Based on the types of bias that are inherent in some study designs we can rank different study designs based on their validity. The types of research studies at the top of the list have the highest validity while those at the bottom have lower validity. In most cases if 2 studies on the same topic come to different conclusions, you assume the trial of the more valid type is correct. However, this is not always the case. Any study design can have bias. A very well designed and executed cohort study can yield more valid results than a clinical trial with clear deficiencies. • Meta-analysis of multiple Randomized Trials (Highest Validity) • Randomized Trial • Prospective Cohort Studies • Case Control Studies or Retrospective Cohort • Case Series (Lowest Validity) Meta-analysis is the process of taking results from multiple different studies and combining them to reach a single conclusion. Doing this is sort of like having one huge study with a very large sample size and therefore meta-analysis has higher power than individual studies. Clinical trials are the gold standard of research for therapeutic and preventative interventions. The researchers have a high level of control over most factors. This allows for randomization and blinding which aren't possible in many other study types. Participant's groups are assigned by the researcher in clinical trials while in observational studies "natural conditions" (personal preference, genetics, social determinants, environment, lifestyle ...) assign the group. As we will see later, the incidence in different groups is compared using Relative Risk (RR). Cohort Studies are studies where you first determine whether or not a person has had an exposure and then you monitor the occurrence of health outcomes overtime. It is the observational study design with the highest validity. Cohort is just a fancy name for a group, and this should help you remember this study design. You start with a group of people (some of whom happen to have an exposure and some who don't). Then you follow this group for a certain amount of time and monitor how often certain diseases or health outcomes arise. It is easier to conceptually understand cohort studies that are prospective. However, there are retrospective cohort studies also. In this scenario you identify a group of people in the past. You then first identify whether or not these people had the particular exposure at that point in time and determine whether or not they ended up getting the health outcomes later on. As we will see later, the incidence in different groups in a cohort study is compared using Relative Risk (RR). Case-Control Studies are retrospective and observational. You first identify people who have the health outcome of interest. Then you carefully select a group of controls that are very similar to your diseased population except they don't have that particular disease. Then you try to determine whether or not the participants from each group had a particular exposure in the past. I remember this by thinking that in a case control study you start off knowing whether a person is diseased (a case) or not diseased (a control). There isn't a huge difference between retrospective cohort and case-control. You are basically doing the same steps but in a slightly different order. However, the two study designs are used in different settings. As we will see later, the incidence in different groups in a case-control study is compared using Odds Ratio (OR). A Case-Series is a small collection of individual cases. It is an observational study with a very small sample size and no control group. Basically you are just reviewing the medical records for a few people with a particular exposure or disease. A study like this is good for very rare exposures or diseases. Obviously the small sample size and lack of a control group limits the validity of any conclusions that are made, but in certain situations this is the best evidence that is available. Cross Sectional Studies are different from the others we have discussed. While the other studies measure the incidence of a particular health outcome over time, a cross-sectional study measures Prevalence. In this observational study the prevalence of the exposure and the health outcome are measured at the same time. You are basically trying to figure out how many people in the population have the disease and how many people have the exposure at one point in time. It is hard to determine an association between the exposure and disease just from this information, but you can still learn things from these studies. If the exposure and disease are both common in a particular population it may be worth investing more resources to do a different type of study to determine whether or not there is a causal relationship.
Views: 108392 Stomp On Step 1
Fixed Effects and Random Effects Models
 
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2 main types of statistical models are used to combine studies in a meta-analysis. This video will give a very basic overview of the principles behind fixed and random effects models.
Views: 54589 Terry Shaneyfelt
Eickhoff Simon: Meta-analysis and activation databases
 
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Meta-analysis and activation databases Speaker: Simon Eickhoff, Forschungszentrum Jülich, Germany 1st HBP School 8-14 September 2014 Alpbach, Austria Follow us: Facebook: @hbpeducation Twitter: @hbp_education or visit: https://education.humanbrainproject.eu/ Video recorded by the Human Brain Project Education Office
Views: 196 HBP Education
What are systematic reviews?
 
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Summary: This video explains why systematic reviews are important and how they are done. This includes an explanation of how the effects of interventions are compared in order to provide evidence. Attribution/credits: Prepared by the Cochrane Consumers and Communication Group, La Trobe University and generously support by Cochrane Australia. Written by Jack Nunn and Sophie Hill. cccrg.cochrane.org. Animation by Shakira Moss, Doodler Animation - doodler.com.au
Views: 94030 Cochrane
An overview of "Summary of findings" (SoF) tables in systematic reviews
 
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This is the third part of a Cochrane Learning Live webinar with the aim of increasing familiarity in interpreting findings of network meta-analysis (NMA) through a NMA ‘Summary of findings’ (SoF) tables developed based on principles of the GRADE approach to rating certainty of evidence from NMAs. The presenters on this webinar were Juan José Yepes-Nuñez and Holger J Schünemann from McMaster University
Views: 167 Cochrane Training
Annotation Graphs: A Graph-Based Visualization for Meta-Analysis of Data
 
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User-authored annotations of data can support analysts in the activity of hypothesis generation and sensemaking, where it is not only critical to document key observations, but also to communicate insights between analysts. We present annotation graphs, a dynamic graph visualization that enables meta-analysis of data based on user-authored annotations. The annotation graph topology encodes annotation semantics, which describe the content of and relations between data selections, comments, and tags. We present a mixed-initiative approach to graph layout that integrates an analyst’s manual manipulations with an automatic method based on similarity inferred from the annotation semantics. Various visual graph layout styles reveal different perspectives on the annotation semantics. Annotation graphs are implemented within C8, a system that supports authoring annotations during exploratory analysis of a dataset. We apply principles of Exploratory Sequential Data Analysis (ESDA) in designing C8, and further link these to an existing task typology in the visualization literature. We develop and evaluate the system through an iterative user-centered design process with three experts, situated in the domain of analyzing HCI experiment data. The results suggest that annotation graphs are effective as a method of visually extending user-authored annotations to data meta-analysis for discovery and organization of ideas. https://autodeskresearch.com/publications/annotation-graphs _________________________________ Jian Zhao, Michael Glueck, Simon Breslav, Fanny Chevalier, Azam Khan (2016) Annotation Graphs: A Graph-Based Visualization for Meta-Analysis of Data based on User-Authored Annotations. IEEE Transactions on Visualization and Computer Graphics. To appear. http://dx.doi.org/10.1109/TVCG.2016.2598543 Autodesk Research http://www.autodeskresearch.com
Views: 408 Autodesk Research
USMLE Step 1 Epidemiology Principles: Study Designs
 
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Cross-sectional, cohort and case control studies. See more at www.boardsbeyond.com.
Views: 64860 Boards and Beyond
What is the 80/20 rule in business?
 
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"Pareto's Principle" named after the Italian economist Vilfredo Pareto, suggested by Joseph Juran, helps in identifying and differentiating the productive team from the non-productive ones. Though there are practical limitations to this rule, but still it is used on larger scale in most of the industries to improve performance. The trick is in knowing where to use it and how, which is explained in detail during Paul Robinson’s (http://www.paulrobinson.in) speaking sessions / coaching / training programs. For more details visit http://crashcoursemba.com Business Insights is a series created by Paul Robinson; the ideas shared are from his experience as a motivational speaker, coach, consultant and an author Recommended books: ‘The 80/20 Principle: The Secret to Achieving More with Less’ by Richard Koch https://goo.gl/sdazG9 ‘The Answer - Grow Any Business, Achieve Financial Freedom, and Live an Extraordinary Life’ by John Assaraf & Murray Smith https://goo.gl/xhkirP
Views: 9436 Positive Revolution
Analysis: The Need for Community
 
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Support on Patreon: http://bit.ly/2rfySih Join the Core-A Gaming Discord: https://discord.gg/coreagaming How communities work and how belongingness affects us. My deepest thanks to Chris Field, DeimosClay, Elliott Seifert, Flan, Jack Vurinars, Jamaal Graves, James Moos, Jarred Rodriguez, Jorge Gutierrez, Jubs, Justin Sison, Kajaanan Mahendrarajah, Koungnak Baek, Macster085, Matt Bahr, Octavian Bancescu, Real Soviet Bear, Sam Not-Sam, Shnooble, Sonic Kurosaki, Syahir bin Selamat, WoodenFence, Yu Gao, Zmaster91, and everyone else who pledged on Patreon! The Art of Community: Seven Principles for Belonging [Kindle] - https://amzn.to/2Qlzvnq [Paperback] - https://amzn.to/2DKq6En Thank you L'Orange for the sick music! Check out his stuff here: https://lorangeproductions.com/ Thanks to Freeplay Arcade in Arlington, TX for the hospitality and good games: https://www.facebook.com/freeplayarlington/ Thanks to UYU for being a great sponsor! Twitter: @UYU_GG Youtube: https://www.youtube.com/channel/UCXL3hR3RHuEehln53ZMvLhw Sources: Roundtable with Mike Ross and Tafokints: https://youtu.be/fPW35tSRRCw?t=10m11s Lie Witness News - Coachella 2013: https://www.youtube.com/watch?v=W_IzYUJANfk Ghost of Marvel: https://www.youtube.com/watch?v=lxlWsxqyRaQ Canada Cup issues lifetime ban: https://www.eventhubs.com/news/2017/nov/02/canada-cup-issues-lifetime-ban-both-players-involved/ Evo 2017 Panel: The History of EVO - https://www.youtube.com/watch?v=zQWn2bBDmMQ The evolution of extreme cooperation via shared dysphoric experiences - https://www.nature.com/articles/srep44292 Penn State Fraternity Hazing Death of Timothy Piazza - https://www.youtube.com/watch?v=vgluRNUhPxc Evo 2018 Tekken Top 8 LilMajin vs JDCR - https://www.youtube.com/watch?v=wQq1dvf3nKI The Dillinger Escape Plan - 43% Burnt live @ The First Unitarian Church: https://www.youtube.com/watch?v=JMnqhJCzEOg Dunbar's Number: https://www.npr.org/2011/06/04/136723316/dont-believe-facebook-you-only-have-150-friends Tenacious D - To Be The Best [Mockumentary] - https://www.youtube.com/watch?v=nai7w1frB1E Keanu Reeves in subway - https://www.youtube.com/watch?v=EMB1EOnUwX8 Football players hazing freshman: https://www.nbcchicago.com/news/national-international/Northbridge-Mass-Football-Players-Accused-of-Hazing-221353191.html Apple becomes first trillion dollar company: https://www.theguardian.com/technology/2018/aug/02/apple-becomes-worlds-first-trillion-dollar-company Loneliness more deadly than smoking: https://toronto.citynews.ca/2018/01/18/epidemic-loneliness-deadly-smoking-study-finds/ Altruistic social interest behaviors are associated with better mental health - https://www.ncbi.nlm.nih.gov/pubmed/14508020 Warren Buffet 3.3 million dollar lunch - https://www.cnbc.com/2018/06/02/lunch-with-warren-buffett-auctions-for-3-point-3-million-dollars.html Warren Buffet charity lunch auction - https://www.ebay.com/rpp/glide Warren Buffet advice from 2007 charity lunch: https://www.cnbc.com/2018/02/23/3-things-two-men-learned-from-their-650000-lunch-with-warren-buffett.html Follow me on Twitter: @CoreAGaming Twitch: https://twitch.tv/coreagaming Buy a t-shirt: https://shop.spreadshirt.com/coreagaming Facebook: http://www.facebook.com/coreagaming BGM in order: Street Fighter V - G Theme Street Fighter III: 3rd Strike - Makoto Theme Mega Max X - Sigma Fortress 1 Fighting EX Layer - Garuda Cave Theme L'Orange - Blame the Author [Unreleased Instrumental] Street Fighter III: 2nd Impact - Alex/Ken Theme L'Orange - Something Different Instrumental LIF Rising Thunder - Edge Theme
Views: 106928 Core-A Gaming
Utilitarianism: Crash Course Philosophy #36
 
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Our next stop in our tour of the ethical lay of the land is utilitarianism. With a little help from Batman, Hank explains the principle of utility, and the difference between act and rule utilitarianism. Get your own Crash Course Philosophy mug or Chom Chom shirt from DFTBA: https://store.dftba.com/collections/crashcourse The Latest from PBS Digital Studios: https://www.youtube.com/playlist?list=PL1mtdjDVOoOqJzeaJAV15Tq0tZ1vKj7ZV -- Produced in collaboration with PBS Digital Studios: http://youtube.com/pbsdigitalstudios -- Want to find Crash Course elsewhere on the internet? Facebook - http://www.facebook.com/YouTubeCrashC... Twitter - http://www.twitter.com/TheCrashCourse Tumblr - http://thecrashcourse.tumblr.com Support CrashCourse on Patreon: http://www.patreon.com/crashcourse CC Kids: http://www.youtube.com/crashcoursekids
Views: 1422099 CrashCourse
Literature Review, The Principles to Medical Research and Publication, Part I
 
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An effective Literature Review saves a lot of unnecessarily work, and effort. This video gives the fundamentals to conduct this discipline effectively. You can follow us on: https://www.facebook.com/Research-School-for-Medical-Professionals-279200612536969/?ref=bookmarks
Views: 494 Mohamed Elawdy
Using Model Based Meta Analysis to Inform Drug Development for Auto Immune Diseases
 
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The difference between getting a new medication to patients, and it ending up in the scrap heap of failed programs lies in making the right choices. There is a surfeit of publicly available information on approved drugs as well as those currently in development. How can sponsors turn clinical trial data into understanding that helps chart the course for investigational drugs? Model-based meta-analysis (MBMA) is a quantitative framework for leveraging external data to inform drug development decisions. This strategy involves a systematic search and tabulation of summary results from public sources which may be combined with proprietary clinical trial data. These data are then analyzed to characterize the impacts of drug class, drug, dose, and time on the response(s) of interest. The influence of study population characteristics or the trial conduct may also be explored. The MBMA approach offers two key advantages over classical meta-analyses. First, it supports bridging across studies to allow comparing treatments that may never have been tested in the same clinical trial. Second, MBMA models use pharmacologic principles which incorporate wider spectrum data (dose, observation time, and clinical trial design). In contrast, traditional meta-analysis generally focuses on treatments that were compared within the same trial and on particular doses for each drug. The insights gained via MBMA enable sponsors to design less costly and more precise trials with an eye toward achieving commercial success for both the drug and portfolio. Watch this webinar with Dr. Mark Lovern, Vice President at Certara Strategic Consulting, to learn how leveraging public data can provide value by abbreviating the “cash spiral” inherent to proprietary data. He presented case studies of autoimmune drug development programs that illustrate how MBMA has been successfully used to: -Compare drugs and therapeutic classes -Optimize clinical trial designs -Predict long-term responses based on short-term responses and/or biomarkers -Guide dosing recommendations for unstudied indications or populations
Views: 115 Certara
Using Meta-Analysis to Study Drug Safety and Efficacy
 
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Khalid Eljaaly, PharmD, MS, CAPPS, BCPS, Contagion® Editorial Advisory Board member, postdoctoral research fellow on infectious diseases and antimicrobial stewardship, MS student in clinical translational sciences, the University of Arizona, College of Pharmacy, discusses which studies are ideal to run through a meta-analysis.
Views: 96 Contagion_Live
CH 8 bringing together
 
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Last video lecture from the stats series. It brings all information together and focuses on key principles behind effect sizes and meta-analysis in corpus linguistics.
Views: 10 Vaclav Brezina
Epi 101: Basic Epidemiological Definitions and Principles for Non-Epidemiologists
 
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Texas Immunization Summit - November 5-7, 2014 For those who don't have a background in epidemiology, but are interested in understanding more about the field and how it applies to immunization and vaccine-preventable disease, this session provides an overview of the important definitions and key principles. Presented by: Anil Mangla, PhD, MS, MPH, FRIPH - San Antonio Metropolitan Health District
Views: 7114 Robyn Correll Carlyle
IPPCR 2015: Overview of Clinical Study Design
 
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IPPCR 2015: Overview of Clinical Study Design Air date: Tuesday, October 20, 2015, 5:00:00 PM Category: IPPCR Runtime: 01:29:48 Description: The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues. For more information go to https://ippcr.nihtraining.com/login.php Author: Laura Lee Johnson, Ph.D., FDA Permanent link: http://videocast.nih.gov/launch.asp?19257
Views: 12932 nihvcast
Tal Yarkoni - Automated annotation and meta-analysis of the fMRI literature [...] (2013)
 
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Workshop lecture at Neuroinformatics 2013 in Stockholm, Sweden Workshop title: The informatics underlying meta-analysis and reproducibility in neuroimaging Talk title: Automated annotation and meta-analysis of the fMRI literature: promises and challenges Speaker: Tal Yarkoni, University of Colorado at Boulder, Boulder, CO, United States
Views: 682 INCF
Intention-to-treat analysis: What is it and why is it important?
 
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Intention to treat analysis is explained and its utility is demonstrated in this video
Views: 26008 Terry Shaneyfelt
Rawdota Coaching: 6000 MMR Teaches 3000 MMR - Invoker (Laning Principles)
 
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In this video you see a portion of a coaching session focused on Invoker in the mid lane. Visit my Coaching Form & Site at http://dota2.coach ► PROFESSIONAL COACHING ● http://dota2.coach FILL OUT THE FORM! ● Reddit Thread: https://goo.gl/jb3ohE ● Optional Email to arrange a session or inquire about more: [email protected] ► RAWDOTA SOCIAL MEDIA ● RAWDOTA on Twitter: http://twitter.com/Rawdota ● RAWDOTA on Facebook: http://Facebook.com/Rawdota ● RAWDOTA on Instagram http://www.instagram.com/rawdota/ ► RAWDOTA COMMUNITY ● Join Discord: https://discord.gg/teDHa2q ● Our Website: http://rawdota.us ► FOLLOW HENRY Henry's Twitter: http://twitter.com/henrydota2 Follow on socials: http://twitch.tv/henry http://twitter.com/rawdota (updates) http://twitter.com/henrydota2 http://instagram.com/henrydota2 COACHING ON SALE! Coaching (Limited time! $20/hour) http://rawdota.us/coaching (fill out form) or email: [email protected] to arrange a time Patreon: http://patreon.com/rawdota Join My Community: https://discord.gg/j7VgHMR
Views: 4832 rawdota
AHS17 What's really wrong with the literature and how to fix it - Richard Feinman
 
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The medical literature is currently subject to extensive criticism, nowhere more than in nutrition. While failure in The medical literature is currently subject to extensive criticism, nowhere more than in nutrition. While the widely invoked misuse of statistics contributes, major cause rests with failure to adhere to accepted ideas such as Bradford Hill’s principles and to accept questionable, if not fundamentally foolish standards — intention-to-treat, meta-analysis and statistically significant but biologically meaningless significance. Blame falls on editors whose failure to recognize controversial subjects and to obtain reviewers from both sides constitutes de facto (or intentional) bias. Evidence of bias comes from PubPeer, Letters-to-editors and social media from people with experience and credentials. Fixing things requires: Recognition that the model of (physical) scientific literature is no longer appropriate. More controversial, more tentative, medical reports require post-publication review or periods of tentative acceptance subject to continued public comment. External respected, neutral organizations to codify good practice and to adjudicate conflicts.
Views: 886 AncestryFoundation
Paradox on Race and IQ
 
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Paradox: https://www.youtube.com/watch?v=qrr6yF4gKvI Lead data: http://thealternativehypothesis.org/index.php/2016/12/23/race-iq-and-lead/ Meta-analysis of SNP based heritability estimates for IQ: https://www.gwern.net/Embryo-selection Adoption gains not g loaded: https://www.sciencedirect.com/science/article/pii/S0191886914005248 Black-White IQ gap IS g-loaded: https://benthamopen.com/contents/pdf/TOPSYJ/TOPSYJ-3-9.pdf Stress: http://thealternativehypothesis.org/index.php/2016/04/15/race-and-stress/ Other Sources: http://thealternativehypothesis.org/index.php/2017/01/07/race-and-iq-the-case-for-genes/
Views: 2800 Sean Last
Natural Law Theory: Crash Course Philosophy #34
 
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Our exploration of ethical theories continues with another theistic answer to the grounding problem: natural law theory. Thomas Aquinas’s version of this theory says that we all seek out what’s known as the basic goods and argued that instinct and reason come together to point us to the natural law. There are, of course, objections to this theory – in particular, the is-ought problem advanced by David Hume. Get your own Crash Course Philosophy mug or Chom Chom shirt from DFTBA: https://store.dftba.com/collections/crashcourse The Latest from PBS Digital Studios: https://www.youtube.com/playlist?list=PL1mtdjDVOoOqJzeaJAV15Tq0tZ1vKj7ZV -- Produced in collaboration with PBS Digital Studios: http://youtube.com/pbsdigitalstudios -- Want to find Crash Course elsewhere on the internet? Facebook - http://www.facebook.com/YouTubeCrashC... Twitter - http://www.twitter.com/TheCrashCourse Tumblr - http://thecrashcourse.tumblr.com Support CrashCourse on Patreon: http://www.patreon.com/crashcourse CC Kids: http://www.youtube.com/crashcoursekids
Views: 631468 CrashCourse
Evidence-Based Practice: Improving Practice, Improving Outcomes (Part One)
 
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In Part 1, by Anne Dabrow Woods, MSN, RN, CRNP, ANP-BC, Chief Nurse, Wolters Kluwer Health, Ovid and Lippincott Williams & Wilkins, introduces the principles of Evidence Based Practice.
Views: 105300 OvidWoltersKluwer
The Difference Principle illustrated
 
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A very simple example, illustrating the Difference Principle. Screencast by Toby Handfield
Views: 12715 Toby Handfield
IPPCR 2015: Welcome & History of Clinical Research: A Merging of Diverse Cultures
 
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Introduction to the Principles and Practice of Clinical Research (IPPCR) 2015: Welcome & History of Clinical Research: A Merging of Diverse Cultures Air date: Tuesday, October 13, 2015, 5:00:00 PM Category: IPPCR Runtime: 01:02:29 Description: The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues. For more information go to https://ippcr.nihtraining.com/login.php Author: John I. Gallin, M.D., NIH Permanent link: http://videocast.nih.gov/launch.asp?19233
Views: 15063 nihvcast
Thinking about thinking: check your mental jenga | Andrew Smyth | TEDxCambridgeUniversity
 
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First principles thinking, i.e. going back to the most fundamental truths, is instilled in us when we leave Cambridge - but are we right to unquestioningly follow the intellectual Giants that came before us? Since completing his Engineering Degree at Cambridge University, Andrew works as an Aerospace Engineer at Rolls-Royce where he analyses jet engines. He has a passion for how things work and is currently pursuing opportunities in Science broadcasting. Best known as a finalist on the seventh series of The Great British Bake Off. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx
Views: 8774 TEDx Talks
What is BEHAVIOR MODIFICATION? What does BEHAVIOR MODIFICATION mean?
 
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What is BEHAVIOR MODIFICATION? What does BEHAVIOR MODIFICATION mean? BEHAVIOR MODIFICATION meaning - BEHAVIOR MODIFICATION definition - BEHAVIOR MODIFICATION explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/by-sa/3.0/ license. Behavior modification is based on methodological behaviorism, which refers to limiting behavior-change procedures to behaviors that are observable and was employed briefly during the late 1950s but predominately from the late 1970s to early 1980s. Specifically, behavior was modified through the use of presumed consequences, including positive and negative reinforcement contingencies to increase desirable behavior or by administering extinction and/or punishment to reduce behavior. In contrast to behavior analysis, analyzing the behavior-environment interactions (including antecedent stimuli) was not considered relevant in behavior modification; it also lacked the conceptual piece (radical behaviorism) initially purposed by B. F. Skinner. Subsequently, applied behavior analysis (ABA) has superseded the early term behavior modification since the 1990s. The first use of the term behavior modification appears to have been by Edward Thorndike in 1911. His article Provisional Laws of Acquired Behavior or Learning makes frequent use of the term "modifying behavior". Through early research in the 1940s and the 1950s the term was used by Joseph Wolpe's research group. The experimental tradition in clinical psychology used it to refer to psycho-therapeutic techniques derived from empirical research. It has since come to refer mainly to techniques for increasing adaptive behavior through reinforcement and decreasing maladaptive behavior through extinction or punishment (with emphasis on the former). Emphasizing the empirical roots of behavior modification, some authors consider it to be broader in scope and to subsume the other two categories of behavior change methods. In recent years, the concept of punishment has had many critics, though these criticisms tend not to apply to negative punishment (time-outs) and usually apply to the addition of some aversive event. The use of positive punishment by board certified behavior analysts is restricted to extreme circumstances when all other forms of treatment have failed and when the behavior to be modified is a danger to the person or to others (see professional practice of behavior analysis). In clinical settings positive punishment is usually restricted to using a spray bottle filled with water as an aversive event. When misused, more aversive punishment can lead to affective (emotional) disorders, as well as to the receiver of the punishment increasingly trying to avoid the punishment (i.e., "not get caught"). Behavior modification relies on the following: 1. Reinforcement (Positive and Negative); 2. Punishment (Positive and Negative); 3. Extinction; 4. Shaping; 5. Fading; and 6. Chaining. Functional behavior assessment forms the core of applied behavior analysis. Many techniques in this therapy are specific techniques aimed at specific issues. Interventions based on behavior analytic/modification principles have been extremely effective in developing evidence-based treatments. In addition to the above, a growing list of research-based interventions from the behavioral paradigm exist. With children with attention deficit hyperactivity disorder (ADHD), one study showed that over a several year period, children in the behavior modification group had half the number of felony arrests as children in the medication group. These findings have yet to be replicated, but are considered encouraging for the use of behavior modification for children with ADHD. There is strong and consistent evidence that behavioral treatments are effective for treating ADHD. A recent meta-analysis found that the use of behavior modification for ADHD resulted in effect sizes in between group studies (.83), pre-post studies (.70), within group studies (2.64), and single subject studies (3.78) indicating behavioral treatments are highly effective.
Views: 7796 The Audiopedia
MPG Primer: GWAS and secondary analyses of GWAS results (2017)
 
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September 28th, 2017 MPG Primer: GWAS and secondary analyses of GWAS results Gina Peloso Broad Institute Boston University School of Public Health MPG Primer: The Primer on Medical and Population Genetics is a series of informal weekly discussions of basic genetics topics that relate to human populations and disease. Experts from across the Broad Institute community give in-depth introductions to the basic principles of complex trait genetics, including human genetic variation, genotyping, DNA sequencing methods, statistics, data analysis, and more. Videos of these sessions are made freely available for viewing here and are geared toward a wide audience that includes research technicians, graduate students, postdoctoral fellows, and established investigators just entering the field. If you'd like more information about the primers visit: https://www.broadinstitute.org/scientific-community/science/programs/medical-and-population-genetics/primers/primer-medical-and-pop Copyright Broad Institute, 2017. All rights reserved.
Views: 1501 Broad Institute
InnoCos USA opening remarks by Sourabh Sharma, SKIM
 
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BRING YOUR INNOVATION TO MARKET: LEVERAGING CONSUMER INSIGHTS FROM NEW PRODUCT DEVELOPMENT TO MARKETING New innovations require a deep understanding of the consumer in many phases of a product's life cycle, from product development to launch. Understanding how to communicate a product's benefits, how to exemplify the reasons to believe, and how to best position an innovative offering is key in recognizing what triggers your consumers. Using an example of on-pack packaging communication, an interactive case study will allow you to participate in evaluating claims, followed by a workshop to learn the principles of creating effective claims. These principles have been derived from SKIM's meta-analysis on claims across multiple consumer product industries. The analysis evoked learnings including the benefit of using a tangible promise of value, versus commonly used communication elements such as comparative advertising and several other pitfalls. While these principles will be applied to on-pack claims and related messaging, they can also be applied to communications testing across every phase of the product life cycle. In this way, the workshop will exemplify the need to derive consumer insight across multiple phases of the product life cycle, so that you can successfully bring your innovation to market. Sourabh Sharma, Social Media Research Expert and Project
Views: 105 INNOCOS events
Macroeconomics of Natural Disasters: Meta-Analysis and Policy Options
 
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Peter van Bergeijk International Institute of Social Studies Erasmus University Rotterdam
Depression and Emotional Upset. What Really Works to Reverse it - Margaret Paul & Irving Kirsch
 
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Expert Panel Host: Irving Kirsch, Margaret Paul • Depression and emotional upset, what really works to reverse it according to the unbiased research and real world results working with thousands of patients. • Margaret Paul - Heal the aloneness, emptiness, and false beliefs that lead to addictive behavior. You can heal past wounds by re-parenting the Inner Child and overcome obstacles that prevent you from progressing in life. Based on the pioneering principles featured in Healing Your Aloneness and Inner Bonding Margaret Paul gently guides you through a powerful spiritual healing process. She teaches you how to connect with your own Inner Child, your loving Adult, and our Higher Power ultimately to create loving relationships with others. This process allows an integrated self to emerge, one that combines the playfulness, creativity, and intuition of a child with the wisdom, strength, and nurture of a loving Adult. Margaret Paul shows how anyone can reconnect with his or her Inner Child to short-circuit self-destructive patterns, resolve fears and conflicts, and build satisfying relationships. Margaret outlines a self-healing process that can be used every day to restore a nurturing balance between loving Adult and loved Inner Child. Irving Kirsch - How does one explain the power of placebo effects in medication and psychotherapy research? Why do people with medical illnesses who strongly anticipate getting better really do? Response expectancies, those unconscious subjective expectations about substances, processes and social stimuli, actually affect autonomic functioning and may be the key to how we ultimately understand the biochemistry of hope. Irving Kirsch brings together the information from scientists who have studied this effect. Margaret Paul, Ph.D. is a relationship expert, best-selling author, and co-creator of the powerful Inner Bonding® healing process, recommended by actress Lindsay Wagner and singer Alanis Morissette, and featured on Oprah, and of the unique and popular website www.innerbonding.com. She has counseled individuals and couples, and led groups, classes, and workshops for the last 44 years, and continues to work on the phone and Skype with clients from all over the world. She is the author/co-author of eight books, including the internationally best-selling “Do I Have To Give Up Me To Be Loved By You?”, “Healing Your Aloneness”, “Inner Bonding”, and “Do I Have To Give Up Me To Be Loved By God?” In 2010, Dr. Margaret completed a 12 year project call SelfQuest®, which is a transformational self-healing/conflict resolution software program. SelfQuest® is being donated to prisons and schools and sold to individuals, families, and businesses – www.selfquest.com. In addition, Margaret offers a powerful 12-week relationship eCourse, “The Intimate Relationship Toolbox”, at http://innerbonding.com/relationshipmicro/, and an equally powerful 12-week weight loss eCourse at http://innerbonding.com/permanent-weightloss-program/. Margaret has three children and three grandchildren. In her spare time, she loves to paint, make pottery, read and ride her horse. Irving Kirsch is Associate Director of the Program in Placebo Studies at the Harvard Medical School, lecturer in medicine at Beth Israel Deaconess Medical Center, Professor of Psychology at the University of Plymouth (UK), and Professor Emeritus at the University of Hull and the University of Connecticut. He has published 10 books and more than 200 scientific journal articles and book chapters on placebo effects, antidepressant medication, hypnosis, and suggestion. He originated the concept of response expectancy. His meta-analyses on the efficacy of antidepressants were covered extensively in the international media and influenced official guidelines for the treatment of depression in the United Kingdom. His book, The Emperor’s New Drugs: Exploding the Antidepressant Myth, which has been published in English, French, Japanese, and Polish, was shortlisted for the prestigious Mind Book of the Year award. It was the topic of 60 Minutes segment on CBS and a 5-page cover story in Newsweek. It is currently being translated into Italian and Turkish.
How to Use SPSS: Intention to Treat Analysis
 
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Introduction to principles and application of intention to treat analysis in randomized, controlled trials.